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DHPS antibody
DHPS
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-DHPS Antibody
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Target
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DHPS
(Deoxyhypusine Synthase (DHPS))
Reactivity
All reactivities for DHPS antibodies
Human
Host
All hosts for DHPS antibodies
Rabbit
Clonality
All clonalities for DHPS antibodies
Polyclonal
Conjugate
All conjugates for DHPS antibodies
This DHPS antibody is un-conjugated
Application
All applications for DHPS antibodies
Western Blotting (WB)
Specificity
This antibody detects endogenous levels of DHS protein. (region surrounding Leu87)
Cross-Reactivity (Details)
Species reactivity (tested):Human.
Purification
Affinity chromatography
Purity
> 95 % by SDS-PAGE
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Discover our top product DHPS Primary Antibody
Alternatives
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Application Details
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Application Notes
Western Blot: 1/500 - 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
1,0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for DHPS
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Target
DHPS
(Deoxyhypusine Synthase (DHPS))
Abstract
DHPS Products
Synonyms
MGC76269 antibody, zgc:56018 antibody, zgc:77325 antibody, wu:fb52g04 antibody, wu:fj48f12 antibody, zgc:111900 antibody, MGC82178 antibody, DDBDRAFT_0186679 antibody, DDBDRAFT_0266388 antibody, DDB_0186679 antibody, DDB_0266388 antibody, DHS antibody, DS antibody, MIG13 antibody, Dhs antibody, DYS antibody, EDA22 antibody, K18J17.7 antibody, K18J17_7 antibody, deoxyhypusine synthase antibody, embryo sac development arrest 22 antibody, deoxyhypusine synthase antibody, deoxyhypusine synthase S homeolog antibody, Deoxyhypusine synthase antibody, DHPS antibody, dhps antibody, dhps.S antibody, SHELL_RS05250 antibody, PF14_0125 antibody, CNJ02480 antibody, Tb10.70.4900 antibody, Tb927.1.870 antibody, MMAH_RS09430 antibody, TAGG_RS03310 antibody, TAGG_RS05175 antibody, Mesil_2448 antibody, Trad_0088 antibody, Igag_1842 antibody, Desac_0724 antibody, MZHIL_RS05480 antibody, MZHIL_RS05835 antibody, MZHIL_RS06250 antibody, Dhps antibody, DHS antibody
Background
Deoxyhypusine synthase (DHS) is crucial for the posttranslational formation of hypusine, a modification of a specific lysine residue in eukaryotic initiation factor 5A (eIF-5A). Hypusine is formed by posttranslational modifications involving two enzymatic steps catalyzed by DHS and deoxyhypusine hydroxylase (DOHH). eIF-5A is essential for eukaryotic cell proliferation. DHS, which belongs to the deoxyhypusine synthase family of proteins, is important for the first step in the hypusine biosynthesis pathway. It acts as a catalyst for the NAD-dependent oxidative cleavage of spermidine and the ensuing transfer of the butylamine moiety of spermidine to the eIF-5A protein, to create the intermediate deoxyhypusine residue.
Molecular Weight
approx. 45 kDa
Gene ID
1725
NCBI Accession
NP_001921
UniProt
P49366
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