TXNIP antibody (AA 116-145)

Catalog No. ABIN3029123

Product Details anti-TXNIP Antibody

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Binding Specificity: AA 116-145

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNIP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): Expected species reactivity: Rat

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 116-145 from the mouse protein was used as the immunogen for this Txnip antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Txnip antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Txnip antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for TXNIP

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Alternative Name: Txnip (TXNIP Products)

Synonyms: EST01027 antibody, HHCPA78 antibody, THIF antibody, VDUP1 antibody, Gm348 antibody, Trf3 antibody, TBP2 antibody, TRF3 antibody, 1200008J08Rik antibody, AA682105 antibody, Hyplip1 antibody, Tbp-2 antibody, Vdup1 antibody, sb:cb368 antibody, txnip antibody, thioredoxin interacting protein antibody, TATA box binding protein like 2 antibody, TATA-box binding protein like 2 antibody, thioredoxin interacting protein L homeolog antibody, thioredoxin interacting protein a antibody, TXNIP antibody, Tbpl2 antibody, TBPL2 antibody, Txnip antibody, txnip.L antibody, txnip antibody, txnipa antibody

Background: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. [UniProt]

UniProt: Q8BG60

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome