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TICAM1 antibody (AA 115-143)

TICAM1 Reactivity: Human, Mouse WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3029184
  • Target See all TICAM1 Antibodies
    TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
    Binding Specificity
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 115-143
    Reactivity
    • 24
    • 8
    • 3
    • 2
    Human, Mouse
    Host
    • 22
    • 3
    • 3
    Rabbit
    Clonality
    • 25
    • 3
    Polyclonal
    Conjugate
    • 21
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TICAM1 antibody is un-conjugated
    Application
    • 20
    • 7
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 115-143 from the human protein was used as the immunogen for this TICAM1 antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product TICAM1 Primary Antibody
  • Application Notes
    Titration of the TICAM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the TICAM1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))
    Alternative Name
    TICAM1 (TICAM1 Products)
    Synonyms
    IIAE6 antibody, MyD88-3 antibody, PRVTIRB antibody, TICAM-1 antibody, TRIF antibody, AW046014 antibody, AW547018 antibody, trif antibody, toll like receptor adaptor molecule 1 antibody, toll-like receptor adaptor molecule 1 antibody, TICAM1 antibody, Ticam1 antibody, ticam1 antibody
    Background
    Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
    UniProt
    Q8IUC6
    Pathways
    TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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