TFE3 antibody (AA 489-516)

Catalog No. ABIN3029201

Product Details anti-TFE3 Antibody

Target: TFE3 (Transcription Factor E3 (TFE3))

Binding Specificity: AA 489-516

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFE3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): Expected species reactivity: Bovine

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 489-516 from the human protein was used as the immunogen for this TFE3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the TFE3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TFE3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for TFE3

Target: TFE3 (Transcription Factor E3 (TFE3))

Alternative Name: TFE3 (TFE3 Products)

Synonyms: RCCP2 antibody, RCCX1 antibody, TFEA antibody, bHLHe33 antibody, F830016E06Rik antibody, Tcfe3 antibody, Tfe-3 antibody, RGD1559642 antibody, cb873 antibody, zgc:109815 antibody, transcription factor binding to IGHM enhancer 3 antibody, transcription factor E3 antibody, transcription factor binding to IGHM enhancer 3 S homeolog antibody, transcription factor binding to IGHM enhancer 3a antibody, TFE3 antibody, Tfe3 antibody, tfe3.S antibody, tfe3a antibody

Background: The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1), it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.

UniProt: P19532