TET1 antibody (C-Term)

Catalog No. ABIN3029115

Product Details anti-TET1 Antibody

Target: TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))

Binding Specificity: C-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TET1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity purified

Immunogen: This mouse Tet1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1845-1879 amino acids from the C-terminal region of mouse Tet1.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Tet1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Tet1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for TET1

Target: TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))

Alternative Name: Tet1 (TET1 Products)

Synonyms: CXXC6 antibody, LCX antibody, bA119F7.1 antibody, 2510010B09Rik antibody, AA517754 antibody, BB001228 antibody, Cxxc6 antibody, D10Ertd17e antibody, mKIAA1676 antibody, tet methylcytosine dioxygenase 1 antibody, solute carrier family 25 member 16 antibody, TET1 antibody, Tet1 antibody, SLC25A16 antibody

Background: Tet1 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. [UniProt]

UniProt: Q3URK3

Pathways: Stem Cell Maintenance, Warburg Effect