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SUMO4 antibody (Met55Val-Mutant)

SUMO4 Reactivity: Human WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3032655
  • Target See all SUMO4 Antibodies
    SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
    Binding Specificity
    • 8
    • 7
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Met55Val-Mutant
    Reactivity
    • 48
    • 18
    • 18
    Human
    Host
    • 45
    • 3
    Rabbit
    Clonality
    • 38
    • 10
    Polyclonal
    Conjugate
    • 24
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This SUMO4 antibody is un-conjugated
    Application
    • 32
    • 22
    • 19
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Purification
    Antigen affinity purified
    Immunogen
    This SUMO4 antibody was produced from rabbits immunized with a KLH conjugated peptide CEPRGLS(V)KQIRFRFG selected from human SUMO4. This antibody is affinity purified using peptides CEPRGLS(V)KQIRFRFG (positive selection) and CEPRGLS(M)KQIRFRFG (negative selection).
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SUMO4 Primary Antibody
  • Application Notes
    Titration of the SUMO4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the SUMO4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
    Alternative Name
    SUMO4 (SUMO4 Products)
    Synonyms
    IDDM5 antibody, SMT3H4 antibody, SUMO-4 antibody, dJ281H8.4 antibody, small ubiquitin-like modifier 4 antibody, small ubiquitin-related modifier 4 antibody, SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) antibody, SUMO4 antibody, sumo4 antibody
    Background
    SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.
    UniProt
    Q6EEV6
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