SUMO2/3 antibody (AA 53-84)

Catalog No. ABIN3032649

Product Details anti-SUMO2/3 Antibody

Target: SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))

Binding Specificity: AA 53-84

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUMO2/3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity (Details): Expected species reactivity: Mouse, Rat, Bovine, Pig, Primate, Chicken, Zebrafish, Hamster, Xenopus

Purification: Purified

Immunogen: A portion of amino acids 53-84 from human SUMO3 was used as the immunogen for this SUMO2/3 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the SUMO2/3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SUMO2/3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for SUMO2/3

Target: SUMO2/3 (Small Ubiquitin Related Modifier 2/3 (SUMO2/3))

Alternative Name: SUMO2/3 (SUMO2/3 Products)

Synonyms: SUMO2 antibody, small ubiquitin-like modifier 2 antibody, SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)-like antibody, small ubiquitin-related modifier 2 antibody, SUMO2 antibody, LOC711990 antibody, LOC714892 antibody

Background: SUMO2 and SUMO3 are members of the SUMO (small ubiquitin-like modifier) protein family. This protein family functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. In vertebrates, three members of the SUMO family have been described, SUMO 1 and the functionally distinct homologues SUMO 2 and SUMO 3. SUMO modification sites present in the N terminal regions of SUMO 2 and SUMO 3 are utilized by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric chains of SUMO 2 and SUMO 3 on protein substrates, a property not shared by SUMO 1.

UniProt: P55854