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NCOA1 antibody (AA 186-214)

NCOA1 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3032056
  • Target See all NCOA1 Antibodies
    NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))
    Binding Specificity
    • 15
    • 7
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 186-214
    Reactivity
    • 66
    • 46
    • 18
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 72
    • 9
    Rabbit
    Clonality
    • 63
    • 18
    Polyclonal
    Conjugate
    • 41
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NCOA1 antibody is un-conjugated
    Application
    • 52
    • 15
    • 13
    • 13
    • 11
    • 8
    • 7
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Cross-Reactivity (Details)
    Expected species reactivity: Pig
    Purification
    Purified
    Immunogen
    A portion of amino acids 186-214 from the human protein was used as the immunogen for this SRC-1 antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product NCOA1 Primary Antibody
  • Application Notes
    Titration of the SRC-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the SRC-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))
    Alternative Name
    SRC-1 (NCOA1 Products)
    Synonyms
    F-SRC-1 antibody, KAT13A antibody, RIP160 antibody, SRC1 antibody, bHLHe42 antibody, bHLHe74 antibody, si:dkey-5g7.6 antibody, si:dkey-34f16.6 antibody, NCOA1 antibody, SRC-1 antibody, nuclear receptor coactivator 1 antibody, NCOA1 antibody, ncoa1 antibody, Ncoa1 antibody
    Background
    SRC-1/NCOA1 is a nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4, the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. [UniProt]
    UniProt
    Q15788
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
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