SOX7 antibody (AA 224-258)

Catalog No. ABIN3032741

Product Details anti-SOX7 Antibody

Target: SOX7 (SRY (Sex Determining Region Y)-Box 7 (SOX7))

Binding Specificity: AA 224-258

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOX7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 224-258 of the human protein was used as the immunogen for the SOX7 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the SOX7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SOX7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for SOX7

Target: SOX7 (SRY (Sex Determining Region Y)-Box 7 (SOX7))

Alternative Name: SOX7 (SOX7 Products)

Synonyms: sox7-A antibody, xSox7 antibody, SRY-box 7 antibody, SRY (sex determining region Y)-box 7 antibody, SRY box 7 antibody, SRY-box 7 L homeolog antibody, SOX7 antibody, Sox7 antibody, sox7 antibody, sox7.L antibody

Background: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3'.

UniProt: Q9BT81

Pathways: Positive Regulation of Endopeptidase Activity