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SMAD2 antibody (AA 97-125)

SMAD2 Reactivity: Human, Mouse WB, ELISA, IF, FACS Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3032613
  • Target See all SMAD2 Antibodies
    SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
    Binding Specificity
    • 51
    • 48
    • 29
    • 27
    • 25
    • 22
    • 9
    • 9
    • 8
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 97-125
    Reactivity
    • 257
    • 168
    • 136
    • 13
    • 11
    • 10
    • 10
    • 8
    • 8
    • 8
    • 7
    • 6
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    Human, Mouse
    Host
    • 257
    • 12
    Rabbit
    Clonality
    • 235
    • 34
    Polyclonal
    Conjugate
    • 123
    • 17
    • 12
    • 10
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    This SMAD2 antibody is un-conjugated
    Application
    • 207
    • 100
    • 64
    • 54
    • 53
    • 43
    • 42
    • 39
    • 17
    • 15
    • 10
    • 8
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)
    Cross-Reactivity (Details)
    Expected species reactivity: Rat, Bovine, Pig, Chicken, Zebrafish, Drosophila
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 97-125 from the human protein was used as the immunogen for this SMAD2 antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SMAD2 Primary Antibody
  • Application Notes
    Titration of the SMAD2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Immunofluorescence: 1:100,Western blot: 1:1000,Flow Cytometry: 1:10-1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the SMAD2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
    Alternative Name
    SMAD2 (SMAD2 Products)
    Synonyms
    JV18 antibody, JV18-1 antibody, MADH2 antibody, MADR2 antibody, hMAD-2 antibody, hSMAD2 antibody, jv18 antibody, Xmad2 antibody, madh2 antibody, madr2 antibody, XSmad2 antibody, hmad-2 antibody, hsmad2 antibody, jv18-1 antibody, smad-2 antibody, fj43c06 antibody, wu:fj43c06 antibody, 7120426M23Rik antibody, Madh2 antibody, Madr2 antibody, Smad-2 antibody, mMad2 antibody, MAD homolog 2 antibody, Mothers against DPP homolog 2 antibody, SMAD 2 antibody, Smad2 antibody, SMAD family member 2 antibody, SMAD family member 2-Z antibody, SMAD family member 2 S homeolog antibody, SMAD2 antibody, SMAD2Z antibody, smad2 antibody, smad2.S antibody, Smad2 antibody
    Background
    Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [UniProt]
    UniProt
    Q15796
    Pathways
    Cell Division Cycle, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
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