PRDM2 antibody (AA 1-347)

Catalog No. ABIN3032300

Product Details anti-PRDM2 Antibody

Target: PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))

Binding Specificity: AA 1-347

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRDM2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Chromatin Immunoprecipitation (ChIP)

Purification: Purified

Immunogen: Purified recombinant GST fusion protein encoding aa 1-347 of human RIZ1. This RIZ1 antibody is specific and does not recognize the beta isoform (RIZ2).

Clone: 33AT1045

Isotype: IgG1

Application Details

Application Notes: Titration of the RIZ1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,ChIP: 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the RIZ1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for PRDM2

Target: PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))

Alternative Name: RIZ1 (PRDM2 Products)

Background: This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt: Q13029