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REST antibody (AA 542-570)
REST
Reactivity: Human
WB, ELISA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-REST Antibody
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Target
See all REST Antibodies
REST
(RE1-Silencing Transcription Factor (REST))
Binding Specificity
All epitopes for REST antibodies
AA 542-570
Reactivity
All reactivities for REST antibodies
Human
Host
All hosts for REST antibodies
Rabbit
Clonality
All clonalities for REST antibodies
Polyclonal
Conjugate
All conjugates for REST antibodies
This REST antibody is un-conjugated
Application
All applications for REST antibodies
Western Blotting (WB), ELISA
Purification
Antigen affinity purified
Immunogen
A portion of amino acids 542-570 from the human protein was used as the immunogen for this REST antibody.
Isotype
Ig Fraction
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Discover our top product REST Primary Antibody
Alternatives
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Application Details
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Application Notes
Titration of the REST antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot the REST antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target Details for REST
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Target
REST
(RE1-Silencing Transcription Factor (REST))
Alternative Name
REST (REST Products )
Synonyms
NRSF antibody, XBR antibody, 2610008J04Rik antibody, AA407358 antibody, xbr antibody, nrsf antibody, rest antibody, resta antibody, REST antibody, RE1 silencing transcription factor antibody, RE1-silencing transcription factor antibody, RE1-silencing transcription factor S homeolog antibody, REST antibody, Rest antibody, rest.S antibody, rest antibody, LOC615792 antibody
Background
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
UniProt
Q13127
Pathways
Negative Regulation of Hormone Secretion , Regulation of Hormone Metabolic Process , Regulation of Hormone Biosynthetic Process , Chromatin Binding , Positive Regulation of Endopeptidase Activity
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