PUMA antibody (AA 119-154)
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- Target See all PUMA (BBC3) Antibodies
- PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
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Binding Specificity
- AA 119-154
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PUMA antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
- Cross-Reactivity (Details)
- Expected species reactivity: Mouse, Rat
- Purification
- Purified
- Immunogen
- A portion of amino acids 119-154 (BH3 domain) from the human protein was used as the immunogen for this Puma antibody.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product BBC3 Primary Antibody
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anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibody
BBC3 Reactivity: Human WB, ICC, IF Host: Rabbit Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 131-180) antibodyBBC3 Reactivity: Human, Rat, Pig WB, ELISA, IP, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 119-154) antibodyBBC3 Reactivity: Human WB, FACS, IHC (p), IF Host: Rabbit Polyclonal RB01353 unconjugated
anti-BCL2 Binding Component 3 (BBC3) (N-Term) antibodyBBC3 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibody (PE)BBC3 Reactivity: Human WB, ICC, IF Host: Rabbit Polyclonal PE
anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibody (PerCP)BBC3 Reactivity: Human WB, ICC, IF Host: Rabbit Polyclonal PerCP
anti-BCL2 Binding Component 3 (BBC3) (N-Term) antibody (Biotin)BBC3 Reactivity: Human WB, IHC Host: Rabbit Polyclonal Biotin
anti-BCL2 Binding Component 3 (BBC3) (BH3 Domain), (C-Term) antibodyBBC3 Reactivity: Human, Mouse WB, FACS, IHC (p), IF, EIA Host: Rabbit Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 109-137) antibodyBBC3 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB33714 unconjugated
anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibodyBBC3 Reactivity: Human, Mouse WB, IHC, ICC, IHC (p) Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Titration of the Puma antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Aliquot the Puma antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Target
- PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
- Alternative Name
- Puma (BBC3 Products)
- Synonyms
- BBC3 antibody, Puma antibody, JFY-1 antibody, JFY1 antibody, PUMA antibody, PUMA/JFY1 antibody, BCL2 binding component 3 antibody, Bcl-2 binding component 3 antibody, BBC3 antibody, Bbc3 antibody, bbc3 antibody
- Background
- PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
- UniProt
- Q9BXH1
- Pathways
- p53 Signaling, Positive Regulation of Endopeptidase Activity
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