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PTEN antibody (pTyr315)
PTEN
Reactivity: Human
DB, ELISA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PTEN Antibody
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Target
See all PTEN Antibodies
PTEN
(Phosphatase and Tensin Homolog (PTEN))
Binding Specificity
All epitopes for PTEN antibodies
pTyr315
Reactivity
All reactivities for PTEN antibodies
Human
Host
All hosts for PTEN antibodies
Rabbit
Clonality
All clonalities for PTEN antibodies
Polyclonal
Conjugate
All conjugates for PTEN antibodies
This PTEN antibody is un-conjugated
Application
All applications for PTEN antibodies
Dot Blot (DB), ELISA
Cross-Reactivity (Details)
Expected species reactivity: Mouse
Purification
Antigen affinity purified
Immunogen
This phospho-PTEN antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY315 of human PTEN.
Isotype
Ig Fraction
Top Product
Discover our top product PTEN Primary Antibody
Alternatives
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anti-Phosphatase and Tensin Homolog (PTEN) (C-Term), (pSer380), (pThr382), (pThr383) antibody
PTEN
Reactivity: Human, Mouse, Rat, Dog, Zebrafish (Danio rerio)
WB, IHC, IF, IP, IC
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Titration of the phospho-PTEN antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
In 1X PBS pH 7.4 with 0.09 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot the phospho-PTEN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target Details for PTEN
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Target
PTEN
(Phosphatase and Tensin Homolog (PTEN))
Alternative Name
PTEN (PTEN Products )
Synonyms
10q23del antibody, BZS antibody, CWS1 antibody, DEC antibody, GLM2 antibody, MHAM antibody, MMAC1 antibody, PTEN1 antibody, TEP1 antibody, 2310035O07Rik antibody, A130070J02Rik antibody, AI463227 antibody, B430203M17Rik antibody, Mmac antibody, PTENP1 antibody, wu:fc52g04 antibody, zgc:73086 antibody, fa11a08 antibody, fb73f10 antibody, fc83f12 antibody, fd16b10 antibody, fk90e11 antibody, pten antibody, si:bz1g13.4 antibody, wu:fa11a08 antibody, wu:fb73f10 antibody, wu:fc83f12 antibody, wu:fd16b10 antibody, wu:fk90e11 antibody, phosphatase and tensin homolog antibody, phosphatase and tensin homolog L homeolog antibody, phosphatase and tensin homolog A antibody, phosphatase and tensin homolog B antibody, PTEN antibody, Pten antibody, pten.L antibody, ptena antibody, ptenb antibody
Background
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
UniProt
P60484
Pathways
TCR Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Inositol Metabolic Process , Synaptic Membrane , Regulation of Cell Size , Autophagy , Platelet-derived growth Factor Receptor Signaling , Signaling of Hepatocyte Growth Factor Receptor , BCR Signaling
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