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LC3C antibody (pSer12)

MAP1LC3C Reactivity: Human ELISA, WB, DB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031792
  • Target See all LC3C (MAP1LC3C) Antibodies
    LC3C (MAP1LC3C) (Microtubule-Associated Protein 1 Light Chain 3 gamma (MAP1LC3C))
    Binding Specificity
    • 15
    • 13
    • 8
    • 6
    • 2
    • 2
    • 2
    • 1
    pSer12
    Reactivity
    • 43
    • 3
    • 2
    Human
    Host
    • 41
    • 1
    • 1
    Rabbit
    Clonality
    • 43
    Polyclonal
    Conjugate
    • 18
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LC3C antibody is un-conjugated
    Application
    • 32
    • 26
    • 8
    • 7
    • 4
    • 4
    • 1
    • 1
    ELISA, Western Blotting (WB), Dot Blot (DB)
    Cross-Reactivity (Details)
    Expected species reactivity: Bovine, Mouse, Rat
    Purification
    Antigen affinity purified
    Immunogen
    This phospho-LC3C antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS12 of human LC3C.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MAP1LC3C Primary Antibody
  • Application Notes
    Titration of the phospho-LC3C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Dot blot: 1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the phospho-LC3C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    LC3C (MAP1LC3C) (Microtubule-Associated Protein 1 Light Chain 3 gamma (MAP1LC3C))
    Alternative Name
    LC3C (MAP1LC3C Products)
    Synonyms
    MAP1LC3C antibody, MGC154878 antibody, ATG8J antibody, LC3C antibody, microtubule associated protein 1 light chain 3 gamma antibody, microtubule associated protein 1 light chain 3 gamma L homeolog antibody, MAP1LC3C antibody, map1lc3c antibody, map1lc3c.L antibody
    Background
    MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole).
    UniProt
    Q9H492
    Pathways
    Autophagy
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