PAK6 antibody (AA 116-146)

Catalog No. ABIN3032122

Product Details anti-PAK6 Antibody

Target: PAK6 (P21-Activated Kinase 6 (PAK6))

Binding Specificity: AA 116-146

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAK6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Purified

Immunogen: A portion of amino acids 116-146 from the human protein was used as the immunogen for this PAK6 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the PAK6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the PAK6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for PAK6

Target: PAK6 (P21-Activated Kinase 6 (PAK6))

Alternative Name: PAK6 (PAK6 Products)

Synonyms: PAK5 antibody, 4732456M09 antibody, pak6 antibody, si:ch211-158b22.3 antibody, p21 (RAC1) activated kinase 6 antibody, p21 protein (Cdc42/Rac)-activated kinase 6 antibody, p21 protein (Cdc42/Rac)-activated kinase 6b antibody, PAK6 antibody, Pak6 antibody, pak6b antibody

Background: The PAK6 protein shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. PAK6 was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.

UniProt: Q9NQU5