NLRP4 antibody (AA 121-149)

Catalog No. ABIN3032022

Product Details anti-NLRP4 Antibody

Target: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Binding Specificity: AA 121-149

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP4 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 121-149 from the human protein was used as the immunogen for this NLRP4 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the NLRP4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the NLRP4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for NLRP4

Target: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Alternative Name: NLRP4 (NLRP4 Products)

Synonyms: CLR19.5 antibody, CT58 antibody, NALP4 antibody, PAN2 antibody, PYPAF4 antibody, RNH2 antibody, Nalp4 antibody, Nlrp4e antibody, RGD1563529 antibody, NLR family pyrin domain containing 4 antibody, NLR family, pyrin domain containing 4 antibody, NLRP4 antibody, Nlrp4 antibody

Background: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).

UniProt: Q96MN2

Pathways: Inflammasome