LSD1 antibody (AA 108-142)
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- Target See all LSD1 (KDM1A) Antibodies
- LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
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Binding Specificity
- AA 108-142
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This LSD1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Purification
- Purified
- Immunogen
- A portion of amino acids 108-142 from the human protein was used as the immunogen for this LSD1 antibody.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product KDM1A Primary Antibody
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anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 130-380) antibody
KDM1A Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 709-876) antibodyKDM1A Reactivity: Human WB, ELISA, IHC, FACS, ICC Host: Mouse Monoclonal 1H2F8 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 55-263) antibodyKDM1A Reactivity: Human WB, ELISA, IHC, FACS, ICC Host: Mouse Monoclonal 3F9D2 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 55-263) antibodyKDM1A Reactivity: Human WB, ELISA, IHC, FACS, ICC Host: Mouse Monoclonal 3F9A3 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 130-380) antibodyKO Validated KDM1A Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 819-852), (C-Term) antibodyKDM1A Reactivity: Human WB, IF, IHC (p) Host: Rabbit Polyclonal RB7583 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 753-851) antibodyKDM1A Reactivity: Human WB, ELISA, IF, IHC (p) Host: Mouse Monoclonal 2E7 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 819-852) antibodyKDM1A Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 108-142), (N-Term) antibodyKDM1A Reactivity: Human, Mouse WB, IF, IHC (p) Host: Rabbit Polyclonal RB7579-RB7580 unconjugated
anti-Lysine (K)-Specific Demethylase 1A (KDM1A) (AA 100-150) antibodyKDM1A Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Titration of the LSD1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Immunofluorescence: 1:10-1:50
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Aliquot the LSD1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Target
- LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
- Alternative Name
- LSD1 (KDM1A Products)
- Background
- LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.
- UniProt
- O60341
- Pathways
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effect
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