JMJD4 antibody (AA 1-30)

Catalog No. ABIN3031514

Product Details anti-JMJD4 Antibody

Target: JMJD4 (Jumonji Domain Containing 4 (JMJD4))

Binding Specificity: AA 1-30

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JMJD4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Purified

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this JMJD4 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the JMJD4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the JMJD4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for JMJD4

Target: JMJD4 (Jumonji Domain Containing 4 (JMJD4))

Alternative Name: JMJD4 (JMJD4 Products)

Background: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

UniProt: Q9H9V9