MAVS antibody (AA 1-30)

Catalog No. ABIN3031815

Product Details anti-MAVS Antibody

Target: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Binding Specificity: AA 1-30

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAVS antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 1-30 from the mouse protein was used as the immunogen for this Ips-1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Ips-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Ips-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for MAVS

Target: MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))

Alternative Name: Ips-1 (MAVS Products)

Background: Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis (By similarity).

UniProt: Q8VCF0

Pathways: Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C