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IGHM antibody (AA 103-131)

IGHM Reactivity: Human IHC, WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031293
  • Target See all IGHM products
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    Binding Specificity
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 103-131
    Reactivity
    • 25
    • 1
    • 1
    Human
    Host
    • 14
    • 11
    Rabbit
    Clonality
    • 17
    • 8
    Polyclonal
    Conjugate
    • 21
    • 1
    • 1
    • 1
    • 1
    This IGHM antibody is un-conjugated
    Application
    • 12
    • 11
    • 10
    • 8
    • 7
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), ELISA
    Purification
    Purified
    Immunogen
    A portion of amino acids 103-131 from the human protein was used as the immunogen for this IGHM antibody.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the IGHM antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the IGHM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    IGHM (Immunoglobulin Heavy Constant mu (IGHM))
    Alternative Name
    IGHM (IGHM Products)
    Synonyms
    AI326478 antibody, Igh-6 antibody, Igh-M antibody, Igh6 antibody, Igm antibody, muH antibody, ighm1 antibody, wu:fj14a08 antibody, zgc:101769 antibody, AGM1 antibody, MU antibody, VH antibody, immunoglobulin heavy constant mu antibody, Ighm antibody, ighm antibody, IGHM antibody
    Background
    IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30 % of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. [UniProt]
    UniProt
    P01871
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