HES1 antibody (AA 102-137)
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- Target See all HES1 Antibodies
- HES1 (Hes Family bHLH Transcription Factor 1 (HES1))
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Binding Specificity
- AA 102-137
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Reactivity
- Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HES1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Cross-Reactivity (Details)
- Expected species reactivity: Bovine, Human, Rat, Xenopus
- Purification
- Antigen affinity purified
- Immunogen
- This mouse Hes1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 102-137 amino acids from the Central region of mouse Hes1.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product HES1 Primary Antibody
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- Application Notes
- Titration of the Hes1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Aliquot the Hes1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Target
- HES1 (Hes Family bHLH Transcription Factor 1 (HES1))
- Alternative Name
- Hes1 (HES1 Products)
- Synonyms
- HES-1 antibody, HHL antibody, HRY antibody, bHLHb39 antibody, Hry antibody, HAIRY1 antibody, c-hairy1A antibody, Xhairy1 antibody, hairy1 antibody, hes1 antibody, Xhairy-1 antibody, Xlh1 antibody, hes family bHLH transcription factor 1 antibody, hairy and enhancer of split 1 (Drosophila) antibody, hes family bHLH transcription factor 4 antibody, hes family bHLH transcription factor 1 S homeolog antibody, hes family bHLH transcription factor 1 L homeolog antibody, HES1 antibody, Hes1 antibody, HES4 antibody, hes1.S antibody, hes1.L antibody
- Background
- Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).
- UniProt
- P35428
- Pathways
- DNA Damage Repair
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