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HAS1 antibody (AA 166-193)

HAS1 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031258
  • Target See all HAS1 Antibodies
    HAS1 (Hyaluronan Synthase 1 (HAS1))
    Binding Specificity
    • 16
    • 7
    • 6
    • 6
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 166-193
    Reactivity
    • 48
    • 23
    • 22
    • 5
    • 5
    • 4
    • 2
    • 1
    Human
    Host
    • 43
    • 6
    Rabbit
    Clonality
    • 43
    • 6
    Polyclonal
    Conjugate
    • 17
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HAS1 antibody is un-conjugated
    Application
    • 25
    • 25
    • 19
    • 13
    • 13
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA
    Cross-Reactivity (Details)
    Expected species reactivity: Mouse
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 166-193 from the human protein was used as the immunogen for this HAS1 antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product HAS1 Primary Antibody
  • Application Notes
    Titration of the HAS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the HAS1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    HAS1 (Hyaluronan Synthase 1 (HAS1))
    Alternative Name
    HAS1 (HAS1 Products)
    Synonyms
    dg42 antibody, Xhas1 antibody, HAS antibody, shas1 antibody, hyaluronan synthase 1 antibody, hyaluronan synthase 1 S homeolog antibody, has1 antibody, HAS1 antibody, Has1 antibody, has1.S antibody
    Background
    Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.
    UniProt
    Q92839
    Pathways
    Glycosaminoglycan Metabolic Process
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