GDNF antibody (AA 8-36)

Catalog No. ABIN3031042

Product Details anti-GDNF Antibody

Target: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Binding Specificity: AA 8-36

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GDNF antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 8-36 from the human protein was used as the immunogen for this GDNF antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the GDNF antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the GDNF antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for GDNF

Target: GDNF (Glial Cell Line Derived Neurotrophic Factor (GDNF))

Alternative Name: GDNF (GDNF Products)

Synonyms: gdnf antibody, GDNF antibody, AI385739 antibody, gdnfa antibody, hfb1-gdnf antibody, ATF1 antibody, ATF2 antibody, HFB1-GDNF antibody, HSCR3 antibody, glial cell derived neurotrophic factor antibody, glial cell derived neurotrophic factor a antibody, glial cell line derived neurotrophic factor antibody, glial cell derived neurotrophic factor L homeolog antibody, Gdnf antibody, gdnfa antibody, GDNF antibody, gdnf.L antibody

Background: GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described.

UniProt: P39905

Pathways: RTK Signaling, Synaptic Membrane, Tube Formation, Autophagy, Smooth Muscle Cell Migration