MAPK7 antibody (AA 527-557)

Catalog No. ABIN3031833

Product Details anti-MAPK7 Antibody

Target: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Binding Specificity: AA 527-557

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPK7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Purified

Immunogen: A portion of amino acids 527-557 from the human protein was used as the immunogen for this ERK4 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the ERK4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the ERK4 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for MAPK7

Target: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Alternative Name: ERK4 (MAPK7 Products)

Synonyms: BMK1 antibody, ERK4 antibody, ERK5 antibody, PRKM7 antibody, Erk5-T antibody, ATMPK7 antibody, F8D23.5 antibody, F8D23_5 antibody, MAP kinase 7 antibody, Bmk1 antibody, Erk5 antibody, Prkm7 antibody, ERK-5 antibody, bmk1 antibody, erk4 antibody, mapk7 antibody, prkm7 antibody, mitogen-activated protein kinase 7 antibody, MAP kinase 7 antibody, mitogen-activated protein kinase 7 L homeolog antibody, MAPK7 antibody, Mapk7 antibody, MPK7 antibody, mapk7.L antibody

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The CMGC group consists of 60 kinases including the cyclin-dependent kinase (CDK) and close relatives family, the MAP kinase (ERK) family, the glycogen synthase kinase 3 (GSK3) family, and the Cdc2-like kinase (CLK) family.

UniProt: P31152

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, cAMP Metabolic Process, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling