EPR1 antibody (AA 308-337)

Catalog No. ABIN3030795

Product Details anti-EPR1 Antibody

Target: EPR1 (Early-Phytochrome-Responsive1 (EPR1))

Binding Specificity: AA 308-337

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Purified

Immunogen: A portion of amino acids 308-337 from the human protein was used as the immunogen for this EPR1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the EPR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the EPR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for EPR1

Target: EPR1 (Early-Phytochrome-Responsive1 (EPR1))

Alternative Name: EPR1 (EPR1 Products)

Background: Cellular receptors for blood proteases regulate chemotaxis, extracellular proteolysis, and growth behavior of normal and malignant cells. Effector cell protease receptor-1 (EPR1) is a receptor for the coagulation protease factor Xa. EPR1 is characterized by a cysteine-rich extracellular module, a single membrane-spanning domain, and a serine-rich cytoplasmic tail featuring at least 15 potential phosphorylation sites. EPR1 also contains 2 N-linked glycosylation sites, 4 O-linked glycosylation sites, and a chondroitin sulfate attachment site, which may provide anchoring for carbohydrate chains, EPR1 transfectants bind to factor Xa in a specific and saturable manner, and in the absence of factor V/Va promote prothrombin activation in a factor Xa concentration-dependent reaction. Activated platelets and megakaryocytes express EPR1. Both EPR1 and membrane-bound factor Va are thought to be required to mediate factor Xa binding to the activated platelet to form a functional prothrombinase complex.

UniProt: Q14868

Pathways: Apoptosis, Cell Division Cycle