DDR1 antibody (AA 299-330)
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- Target See all DDR1 Antibodies
- DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))
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Binding Specificity
- AA 299-330
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DDR1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
- Purification
- Purified
- Immunogen
- A portion of amino acids 299-330 from the human protein was used as the immunogen for this DDR1 antibody.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product DDR1 Primary Antibody
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anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 17-47), (N-Term) antibody
DDR1 Reactivity: Human, Rat WB, IHC (p), FACS Host: Rabbit Polyclonal RB01477 unconjugated
anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 299-330) antibodyDDR1 Reactivity: Human WB, IHC (p), FACS, IF Host: Rabbit Polyclonal RB14442 unconjugated
anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 568-829) antibodyDDR1 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 21-176) antibodyDDR1 Reactivity: Human ELISA, FACS Host: Mouse Monoclonal 4F2C12 unconjugated
anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 17-47) antibodyDDR1 Reactivity: Human WB, ELISA, IHC, FACS Host: Rabbit Polyclonal unconjugated
anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 21-120) antibodyDDR1 Reactivity: Rat, Mouse WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (C-Term) antibodyDDR1 Reactivity: Human, Rat, Mouse WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (Internal Region) antibodyDDR1 Reactivity: Human, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 602-681) antibodyDDR1 Reactivity: Human ELISA Host: Mouse Monoclonal 2G4E12 unconjugated
anti-Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) (AA 22-876) antibodyDDR1 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
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- Application Notes
- Titration of the DDR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Aliquot the DDR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Target
- DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))
- Alternative Name
- DDR1 (DDR1 Products)
- Background
- Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. DDR1 is an RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. It belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis show that expression of DDR1 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.
- UniProt
- Q08345
- Pathways
- RTK Signaling, Smooth Muscle Cell Migration
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