DCLK2 antibody (AA 167-196)

Catalog No. ABIN3030772

Product Details anti-DCLK2 Antibody

Target: DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))

Binding Specificity: AA 167-196

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCLK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 167-196 from the human protein was used as the immunogen for this DCLK2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the DCLK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the DCLK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for DCLK2

Target: DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))

Alternative Name: DCLK2 (DCLK2 Products)

Synonyms: CL2 antibody, CLICK-II antibody, CLICK2 antibody, CLIK2 antibody, DCAMKL2 antibody, DCDC3 antibody, DCDC3B antibody, DCK2 antibody, 6330415M09Rik antibody, AU044875 antibody, Click-II antibody, Dcamkl2 antibody, DCLK2 antibody, cb572 antibody, dclk antibody, sb:cb572 antibody, si:dkey-180n16.1 antibody, Dck2 antibody, RGD1308384 antibody, doublecortin like kinase 2 antibody, doublecortin-like kinase 2 antibody, doublecortin-like kinase 2a antibody, DCLK2 antibody, Dclk2 antibody, dclk2a antibody

Background: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.

UniProt: Q8N568