Claudin 2 antibody (AA 135-164)

Catalog No. ABIN3030535

Product Details anti-Claudin 2 Antibody

Target: Claudin 2 (CLDN2)

Binding Specificity: AA 135-164

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity (Details): Expected species reactivity: Mouse, Bovine

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 135-164 from the human protein was used as the immunogen for this Claudin 2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Claudin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Claudin 2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for Claudin 2

Target: Claudin 2 (CLDN2)

Abstract: CLDN2 Products

Synonyms: CLDN2 antibody, zgc:92260 antibody, AL022813 antibody, RGD1560247 antibody, claudin 2 antibody, CLDN2 antibody, cldn2 antibody, Cldn2 antibody

Background: Claudin-2 is expressed in cation-leaky epithelia such as that of the kidney proximal tubule. Mice that are deficient in the protein have reduced reabsorption of Na+ in the proximal tubule, consistent with a role in paracellular transport. Similar results have been obtained with cultured cells, as overexpression in CLDN2 lacking cells leads to increase of permeability for small cations. Furthermore, CLDN2 has been shown to form paracellular channels for water. [Wiki]

UniProt: P57739

Pathways: Hepatitis C