BIRC3 antibody (AA 101-131)

Catalog No. ABIN3030108

Product Details anti-BIRC3 Antibody

Target: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Binding Specificity: AA 101-131

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BIRC3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 101-131 from the human protein was used as the immunogen for this cIAP2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the cIAP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the cIAP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for BIRC3

Target: BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))

Alternative Name: cIAP2 (BIRC3 Products)

Background: BIRC3 is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain.

UniProt: Q13489

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades