CCR1 antibody (AA 1-30)

Catalog No. ABIN3030216

Product Details anti-CCR1 Antibody

Target: CCR1 (Chemokine (C-C Motif) Receptor 1 (CCR1))

Binding Specificity: AA 1-30

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this CCR1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the CCR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CCR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for CCR1

Target: CCR1 (Chemokine (C-C Motif) Receptor 1 (CCR1))

Alternative Name: CCR1 (CCR1 Products)

Synonyms: CD191 antibody, CKR-1 antibody, CKR1 antibody, CMKBR1 antibody, HM145 antibody, MIP1aR antibody, SCYAR1 antibody, Cmkbr1 antibody, Mip-1a-R antibody, C-C motif chemokine receptor 1 antibody, chemokine (C-C motif) receptor 1 antibody, CCR1 antibody, Ccr1 antibody

Background: CCR1 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.

UniProt: P32246