Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Caspase 12 antibody (AA 165-193)

CASP12 Reactivity: Human WB, ELISA, IHC, FACS, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3030291
  • Target See all Caspase 12 (CASP12) Antibodies
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    Binding Specificity
    • 16
    • 15
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 165-193
    Reactivity
    • 62
    • 52
    • 31
    Human
    Host
    • 89
    • 3
    • 1
    Rabbit
    Clonality
    • 90
    • 3
    Polyclonal
    Conjugate
    • 40
    • 8
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Caspase 12 antibody is un-conjugated
    Application
    • 79
    • 40
    • 28
    • 28
    • 26
    • 26
    • 22
    • 18
    • 10
    • 6
    • 5
    • 5
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
    Purification
    Antigen affinity purified
    Immunogen
    A portion of amino acids 165-193 from the human protein was used as the immunogen for this Caspase-12 antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CASP12 Primary Antibody
  • Application Notes
    Titration of the Caspase-12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Flow Cytometry: 1:10-1:50,Immunofluorescence: 1:10-1:50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the Caspase-12 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    Alternative Name
    Caspase-12 (CASP12 Products)
    Synonyms
    Caspase-12 antibody, CASP-12 antibody, CASP12P1 antibody, caspase 12 antibody, caspase 12 (gene/pseudogene) antibody, Casp12 antibody, CASP12 antibody
    Background
    Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
    UniProt
    Q6UXS9
    Pathways
    Apoptosis, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
You are here:
Support