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ADAM17 antibody (AA 794-823)
ADAM17
Reactivity: Human
WB, ELISA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ADAM17 Antibody
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Target
See all ADAM17 Antibodies
ADAM17
(ADAM Metallopeptidase Domain 17 (ADAM17))
Binding Specificity
All epitopes for ADAM17 antibodies
AA 794-823
Reactivity
All reactivities for ADAM17 antibodies
Human
Host
All hosts for ADAM17 antibodies
Rabbit
Clonality
All clonalities for ADAM17 antibodies
Polyclonal
Conjugate
All conjugates for ADAM17 antibodies
This ADAM17 antibody is un-conjugated
Application
All applications for ADAM17 antibodies
Western Blotting (WB), ELISA
Purification
Antigen affinity purified
Immunogen
A portion of amino acids 794-823 from the human protein was used as the immunogen for this ADAM17 antibody.
Isotype
Ig Fraction
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Discover our top product ADAM17 Primary Antibody
Alternatives
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Application Details
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Application Notes
Titration of the ADAM17 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot the ADAM17 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target Details for ADAM17
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Target
ADAM17
(ADAM Metallopeptidase Domain 17 (ADAM17))
Alternative Name
ADAM17 (ADAM17 Products )
Synonyms
ADAM18 antibody, CD156B antibody, CSVP antibody, NISBD antibody, TACE antibody, CD156b antibody, Tace antibody, adam17 antibody, si:dkey-81b15.2 antibody, adam18 antibody, cd156b antibody, csvp antibody, tace antibody, fc20b01 antibody, wu:fc20b01 antibody, zgc:63886 antibody, ADAM metallopeptidase domain 17 antibody, a disintegrin and metallopeptidase domain 17 antibody, ADAM metallopeptidase domain 17b antibody, ADAM metallopeptidase domain 17 L homeolog antibody, ADAM metallopeptidase domain 17a antibody, ADAM17 antibody, Adam17 antibody, adam17b antibody, adam17.L antibody, adam17a antibody
Background
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. [UniProt]
UniProt
P78536
Pathways
Notch Signaling , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Response to Growth Hormone Stimulus
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