ABCG2
Reactivity: Human, Mouse, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Titration of the ABCG2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50,IHC (Paraffin): 1:50-1:100
Restrictions
For Research Use only
Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot the ABCG2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target
ABCG2
(ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2))
bcrp antibody, ABCG2 antibody, ABC15 antibody, ABCP antibody, BCRP antibody, BCRP1 antibody, BMDP antibody, CD338 antibody, CDw338 antibody, EST157481 antibody, GOUT1 antibody, MRX antibody, MXR antibody, MXR1 antibody, UAQTL1 antibody, AI428558 antibody, Bcrp1 antibody, ABCG3 antibody, ATP binding cassette subfamily G member 2 antibody, ATP binding cassette subfamily G member 2 (Junior blood group) antibody, ATP binding cassette subfamily G member 2 (Junior blood group) L homeolog antibody, ATP-binding cassette, sub-family G (WHITE), member 2 antibody, ATP-binding cassette sub-family G member 2 antibody, ABCG2 antibody, abcg2 antibody, abcg2.L antibody, Abcg2 antibody, LOC100008640 antibody
Background
ABCG2 is a membrane-associated protein included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.