VEGFD (VEGF4) (AA 89-205) antibody
Reactivity: Human
IHC (p), WB
Host: Rabbit
Polyclonal
unconjugated
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- Target
- VEGFD (VEGF4)
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Binding Specificity
- AA 89-205
- Reactivity
- Human
-
Host
- Rabbit
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Clonality
- Polyclonal
-
Conjugate
- Un-conjugated
- Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
- Purification
- Antigen affinity
- Immunogen
- Amino acids 89-205 of human VEGFD were used as the immunogen for the VEGFD antibody.
- Isotype
- IgG
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anti-VEGFD (VEGF4) (AA 322-352), (C-Term) antibody
Reactivity: Human IHC (p), WB Host: Rabbit Polyclonal RB11698 unconjugated
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- Application Notes
- Optimal dilution of the VEGFD antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (FFPE): 1-2 μg/mL
- Restrictions
- For Research Use only
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- Buffer
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- Storage
- -20 °C
- Storage Comment
- After reconstitution, the VEGFD antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
-
- Target
- VEGFD (VEGF4)
- Alternative Name
- VEGFD / VEGF4
- Background
- C-fos induced growth factor (FIGF) (or vascular endothelial growth factor D, VEGFD, VEGF4) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene. The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. Analyzing by Northern blotting, Yamada et al. (1997) symbolized VEGFD, was expressed as a 2.2-kb transcript with highest expression in lung, heart, small intestine, and fetal lung, and lower levels in skeletal muscle, colon, and pancreas. And Achen et al. (1998) concluded that VEGFD was most closely related to VEGFC by virtue of the presence of N- and C-terminal extensions that were not found in other VEGF family members. Stacker et al. (2001) showed that VEGFD can induce tumor angiogenesis through VEGFR2 and tumor lymphangiogenesis through VEGFR3, whereas VEGF, which does not activate VEGFR3, induces only tumor angiogenesis.
- UniProt
- O43915
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