PKC eta antibody (AA 30-389)

Catalog No. ABIN4952175

Product Details anti-PKC eta Antibody

Target: PKC eta (PRKCH) (Protein Kinase C, eta (PRKCH))

Binding Specificity: AA 30-389

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKC eta antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Purification: Antigen affinity

Immunogen: Amino acids 30-389 of human PKC eta were used as the immunogen for the PKC eta antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PKC eta antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,FACS: 1-3 μg/10^6 cells

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the PKC eta antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for PKC eta

Target: PKC eta (PRKCH) (Protein Kinase C, eta (PRKCH))

Alternative Name: PKC eta (PRKCH Products)

Synonyms: PKC-L antibody, PKCL antibody, PRKCL antibody, nPKC-eta antibody, Pkch antibody, pkc-eta antibody, PRKCH antibody, prkch antibody, si:ch211-212g7.5 antibody, zgc:172124 antibody, protein kinase C eta antibody, protein kinase C, eta antibody, protein kinase C eta L homeolog antibody, protein kinase C, eta, b antibody, protein kinase C, eta, a antibody, protein kinase C epsilon antibody, PRKCH antibody, Prkch antibody, prkch.L antibody, prkchb antibody, prkcha antibody, prkch antibody, PRKCE antibody

Background: PRKCH is also known as PKC eta. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. Also, PKC family members serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. And it is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.

UniProt: P24723

Pathways: Myometrial Relaxation and Contraction, Thromboxane A2 Receptor Signaling