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MGMT antibody

MGMT Reactivity: Human WB, IF, IHC (p) Host: Mouse Monoclonal 4C12 unconjugated
Catalog No. ABIN4911931
  • Target See all MGMT Antibodies
    MGMT (O6-Methylguanine-DNA-Methyltransferase (MGMT))
    Reactivity
    • 71
    • 19
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 69
    • 9
    Mouse
    Clonality
    • 62
    • 16
    Monoclonal
    Conjugate
    • 43
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This MGMT antibody is un-conjugated
    Application
    • 53
    • 33
    • 20
    • 20
    • 13
    • 13
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human
    Purification
    Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    Immunogen
    Purified His-tagged MGMT protein was used to produced this monoclonal antibody.
    Clone
    4C12
    Isotype
    IgG1
    Top Product
    Discover our top product MGMT Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IF()
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    MGMT (O6-Methylguanine-DNA-Methyltransferase (MGMT))
    Alternative Name
    MGMT (MGMT Products)
    Synonyms
    AGT antibody, AI267024 antibody, Agat antibody, O-6-methylguanine-DNA methyltransferase antibody, MGMT antibody, Mgmt antibody
    Background

    Synonyms: Methylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase

    Background: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

    Gene ID
    4255
    UniProt
    P16455
    Pathways
    DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus
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