beta Arrestin 1 antibody

Catalog No. ABIN4903044

Product Details anti-beta Arrestin 1 Antibody

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This beta Arrestin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Characteristics: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

Purification: Affinity purification

Immunogen: Recombinant protein of human ARRB1.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 , IHC 1:50-1:100 , ICC 1:50-1:200 , IF 1:50-1:100 , IP 1:20-1:50 , FC 1:20-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C.

Target Details for beta Arrestin 1

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Alternative Name: beta Arrestin 1 (ARRB1 Products)

Synonyms: arrb1 antibody, MGC83787 antibody, arb1 antibody, arr1 antibody, barr1 antibody, betaarr1 antibody, 1200006I17Rik antibody, AW208571 antibody, G430100A01Rik antibody, ARB1 antibody, ARR1 antibody, BARRES antibody, arrestin beta 1 antibody, arrestin, beta 1 antibody, arrestin beta 1 L homeolog antibody, beta-arrestin 1 antibody, putative beta-arrestin 1 antibody, ARRB1 antibody, arrb1 antibody, arrb1.L antibody, CpipJ_CPIJ016988 antibody, CpipJ_CPIJ017114 antibody, Smp_122900 antibody, Smp_126080 antibody, Smp_176980 antibody, Smp_152290 antibody, Arrb1 antibody

Gene ID: 408

UniProt: P49407

Pathways: Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction