MGP antibody (AA 20-96)

Catalog No. ABIN4886666

Product Details anti-MGP Antibody

Target: MGP (Matrix Gla Protein (MGP))

Binding Specificity: AA 20-96

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MGP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Matrix Gla protein(MGP) detection. Tested with WB, IHC-P in Human.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Matrix Gla protein(MGP) detection. Tested with WB, IHC-P in Human.
Gene Name: matrix Gla protein
Protein Name: Matrix Gla protein

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human MGP recombinant protein (Position: Y20-F96). Human MGP shares 84.4% and 80.5% amino acid (aa) sequence identity with mouse and rat MGP, respectively.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for MGP

Target: MGP (Matrix Gla Protein (MGP))

Alternative Name: MGP (MGP Products)

Synonyms: MGLAP antibody, NTI antibody, Mglap antibody, mgp-A antibody, MGP antibody, LOC100136434 antibody, mgp antibody, matrix Gla protein antibody, matrix Gla protein L homeolog antibody, MGP antibody, Mgp antibody, mgp.L antibody, mgp antibody

Background: Matrix Gla protein (MGP) is an 84-residue vitamin K-dependent protein initially isolated from bovine bone. In addition, MGP is a 10-kD protein produced and secreted by vascular smooth muscle cells and chondrocytes and significantly accumulated in bone, cartilage, and dentin. It is also expressed at high levels in heart, kidney, and lung and is upregulated by vitamin D in bone cells. MGP has a high affinity binding to calcium ions, similar to other Gla-containing proteins. The protein acts as an inhibitor of vascular mineralization and plays a role in bone organization. And this gene is mapped to 12p12.3.

Synonyms: GIG36 | Matrix Gla protein | MGLAP | MGP | NTI | P08493

Gene ID: 4256

UniProt: P08493