ADC antibody (AA 111-301)

Catalog No. ABIN4886479

Product Details anti-ADC Antibody

Target: ADC (Arginine Decarboxylase (ADC))

Binding Specificity: AA 111-301

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Antizyme inhibitor 2(AZIN2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Antizyme inhibitor 2(AZIN2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: antizyme inhibitor 2
Protein Name: Antizyme inhibitor 2

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human AZIN2 recombinant protein (Position: C111-Q301). Human AZIN2 shares 89.4% amino acid (aa) sequence identity with mouse AZIN2.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for ADC

Target: ADC (Arginine Decarboxylase (ADC))

Alternative Name: AZIN2 (ADC Products)

Synonyms: MGC134604 antibody, azi2 antibody, odc2 antibody, odc-p antibody, odc1l antibody, xodc2 antibody, ADC antibody, AZI2 antibody, ODC-p antibody, ODC1L antibody, 4933429I20Rik antibody, AZIN2 antibody, Azi2 antibody, B930082O19 antibody, Odcp antibody, RGD1564776 antibody, odc1-b antibody, arginine decarboxylase antibody, antizyme inhibitor 2 antibody, biosynthetic arginine decarboxylase SpeA antibody, biosynthetic arginine decarboxylase SpeA (ADC) antibody, pyruvoyl-dependent arginine decarboxylase antibody, antizyme inhibitor 2 S homeolog antibody, AZIN2 antibody, azin2 antibody, adc antibody, speA antibody, Mrub_2839 antibody, MMAH_RS09440 antibody, Arnit_1968 antibody, Mesil_3114 antibody, Trad_0080 antibody, Spirs_3255 antibody, LOC100233080 antibody, Azin2 antibody, azin2.S antibody

Background: Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine, however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.

Synonyms: ADC | Antizyme inhibitor 2 | ArgDC | Arginine decarboxylase | AZI2 | ODC-p | ODC-paralogue | ODC1L | ODCp | Q96A70

Gene ID: 113451

UniProt: Q96A70