Gestrinone antibody
EIA
Host: Sheep
Polyclonal
unconjugated
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- Target
- Gestrinone
- Reactivity
- Please inquire
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Host
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Sheep
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Clonality
- Polyclonal
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Conjugate
- Un-conjugated
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Application
- Enzyme Immunoassay (EIA)
- Purification
- Ig Fraction
- Immunogen
- Gestrinone-BTG
- Isotype
- IgG
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- Application Notes
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ELISA: 0.039 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 10.20 mg/mL (U.V.abs at 280nm)
- Buffer
- 20 mM Phosphate, 150 mM Sodium Chloride, pH 7.2 containing 0.09 % Sodium Azide as preservative.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- -20 °C
- Storage Comment
- Store the antibody (in aliquots) at-20 °C.
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- Target
- Gestrinone
- Target Type
- Hormone
- Background
- Endometriosis is common disease characterized by the presence of endometrial tissue outside the uterus which affects approximately 10 % of premenopausal women. Gestrinone is a synthetic steroid used occasionally to treat endometriosis.(1) It acts centrally on the hypothalamic-pituitary system to suppress release of lutenizing hormone (LH) and follicle-stimulating hormone (FSH), thus reducing estrogen synthesis.(1) It also binds to androgen (AR), progesterone (PR), and estrogen (ER) receptors in the human endometrial tissue but not to steroid hormone binding globulin or corticord-binding globulin.(2) Gestrinone binds to AR and PR with EC50 values of approximately 20 and 30 nM, respectively.(3) These values reflect approximately 5-6 fold lower affinity than testosterone and progesterone, the natural AR and PR ligands, for these receptors.(3)Synonyms: Dimetriose, Dimetrose, Ethylnorgestrienone, Gestrigone, Gestrinonum, Nemestran, Tridomose
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