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PRR7 antibody (C-Term, Intracellular)

PRR7 Reactivity: Human, Mouse, Rat WB, ICC Host: Mouse Monoclonal TRAP3-10 unconjugated
Catalog No. ABIN457438
  • Target See all PRR7 Antibodies
    PRR7 (Proline Rich 7 (Synaptic) (PRR7))
    Binding Specificity
    • 9
    • 8
    • 7
    • 1
    • 1
    • 1
    C-Term, Intracellular
    Reactivity
    • 20
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 18
    • 2
    Mouse
    Clonality
    • 18
    • 2
    Monoclonal
    Conjugate
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    This PRR7 antibody is un-conjugated
    Application
    • 20
    • 13
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC)
    Specificity
    The mouse monoclonal antibody TRAP3/10 recognizes an epitope located in the C-terminal part of the intracellular domain of PRR7/TRAP3 (amino acids 126-253 of human PRR7 / TRAP3), a 28 kDa proline-rich membrane protein presumably associated with NMDA receptor complex.
    Cross-Reactivity (Details)
    Human, Mouse, Rat
    Purification
    Purified by protein-A affinity chromatography.
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    Recombinant C-terminal half of the intracellular domain of human PRR7/TRAP3 (amino acids 126-253)
    Clone
    TRAP3-10
    Isotype
    IgG2a
  • Application Notes
    Immunocytochemistry: Recommended dilution: 10 μg/mL, cell culture fixed with 4 % paraformaldehyde, permeabilized with 0.1 % Triton-X100.
    Western blotting: Recommended dilution: 1 μg/mL, positive control: murine brain lysate (red. Laemmli buffer).
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Hrdinka, Dráber, Stepánek, Ormsby, Otáhal, Angelisová, Brdicka, Paces, Horejsí, Drbal: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).

  • Target
    PRR7 (Proline Rich 7 (Synaptic) (PRR7))
    Alternative Name
    PRR7 / TRAP3 (PRR7 Products)
    Synonyms
    PRR7 antibody, XM_484263 antibody, proline rich 7, synaptic antibody, proline rich 7 (synaptic) antibody, proline rich 7 (synaptic) L homeolog antibody, PRR7 antibody, prr7 antibody, prr7.L antibody, Prr7 antibody
    Background
    Proline rich 7, synaptic,PRR7/TRAP3 (proline-rich 7, transmembrane adaptor protein 3) is a 28 kDa transmembrane adaptor protein ubiquitously expressed at low level (most in brain). Its amino acid sequence is extremely conserved among mammalian and other species. PRR7/TRAP3 contains potential palmitoylation motif and is found in lipid rafts. It is a part of the complex postsynaptic density fraction in neurons and associates with PSD-95, NMDA receptor and probably other proteins. The intracellular domain of PRR7/TRAP3 contains several tyrosines, a proline-rich sequence, and a C-terminal PDZ-binding motif. So far nothing is known about function of this protein. It may be involved in regulation of some receptor signaling and in formation of neurologic and immunologic synapse.,TRAP3
    Gene ID
    80758
    UniProt
    Q8TB68
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