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PIAS2 antibody (Internal Region)

PIAS2 Reactivity: Human, Mouse, Rat, Dog IHC (p) Host: Goat Polyclonal unconjugated
Catalog No. ABIN452439
  • Target See all PIAS2 Antibodies
    PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
    Binding Specificity
    • 10
    • 10
    • 9
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 58
    • 25
    • 21
    • 10
    • 8
    • 8
    • 8
    • 5
    • 4
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog
    Host
    • 51
    • 6
    • 2
    • 1
    Goat
    Clonality
    • 55
    • 5
    Polyclonal
    Conjugate
    • 44
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PIAS2 antibody is un-conjugated
    Application
    • 47
    • 22
    • 14
    • 7
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody reacts to PIAS2.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse, Rat, Canine.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Immunogen
    Peptide with sequence KEAMKVSSQPCTKIE, from the internal region of the protein sequence
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    Discover our top product PIAS2 Primary Antibody
  • Application Notes
    Peptide ELISA: 1/8000. Immunohistochemistry on paraffin sections: 3 - 5 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0,5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
    Alternative Name
    PIAS2 (PIAS2 Products)
    Synonyms
    MGC83751 antibody, piasx antibody, wu:fi05f09 antibody, PIAS2 antibody, 6330408K17Rik antibody, AI462206 antibody, ARIP3 antibody, AU018068 antibody, Dib antibody, Miz1 antibody, PIASxalpha antibody, PIASxb antibody, PIASxbeta antibody, SIZ2 antibody, DIP antibody, MIZ antibody, MIZ1 antibody, PIASX antibody, PIASX-ALPHA antibody, PIASX-BETA antibody, ZMIZ4 antibody, protein inhibitor of activated STAT 2 L homeolog antibody, protein inhibitor of activated STAT 2 antibody, protein inhibitor of activated STAT, 2 antibody, pias2.L antibody, PIAS2 antibody, pias2 antibody, Pias2 antibody
    Background
    PIAS2 functions as an E3 type small ubiquitin like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO mediated repression of ELK1 transactivation activity. Isoform PIAS2 beta, but not isoform PIAS2 alpha, promotes MDM2 sumoylation. Isoform PIAS2 beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2 alpha.Synonyms: ARIP3, Androgen receptor-interacting protein 3, DAB2-interacting protein, DIP, E3 SUMO-protein ligase PIAS2, Miz1, Msx-interacting zinc finger protein, PIAS-NY protein, PIASX, Protein inhibitor of activated STAT x, Protein inhibitor of activated STAT2
    Gene ID
    9063
    NCBI Accession
    NP_004662
    UniProt
    O75928
    Pathways
    JAK-STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
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