FANCC
Reactivity: Human
WB
Host: Mouse
Polyclonal
unconjugated
Application Notes
ELISA: 1: 20,000 - 1: 80,000. Western blot: 1: 1,000 - 1: 3,000 (Expect a band approximately 63 kDa in size correspondingto FANCC in the appropriate human tissue).
Restrictions
For Research Use only
Concentration
1.45 mg/mL (by UV absorbance at 280 nm)
Buffer
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Target
FANCC
(Fanconi Anemia, Complementation Group C (FANCC))
zgc:154105 antibody, FANCC antibody, fa3 antibody, fac antibody, facc antibody, FA3 antibody, FAC antibody, FACC antibody, BB116513 antibody, Facc antibody, Fanconi anemia complementation group C antibody, Fanconi anemia, complementation group C antibody, Fanconi anemia complementation group C L homeolog antibody, FANCC antibody, fancc antibody, fancc.L antibody, Fancc antibody
Background
FANCC (also called Protein FACC or Fanconi Anemia Group C protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCC may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. FANCC belongs to the multi-subunit Fanconi Anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. FANCC is mainly found within the nucleus although some protein is localized in the cytoplasm. This protein is ubiquitously expressed. Defects in FANCC are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopaenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNAdamaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.Synonyms: FAC, FACC, Fanconi anemia group C protein