UCK antibody (N-Term)

Catalog No. ABIN392730

Product Details anti-UCK Antibody

Target: UCK (Uridine-Cytidine Kinase (UCK))

Binding Specificity: AA 18-48, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UCK antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: B, Pig, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This UCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-48 amino acids from the N-terminal region of human UCK.

Clone: RB3874

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-UCK antibody (ABIN392730)

Zlatopolskiy, Morgenroth, Kunkel, Urusova, Dinger, Kull, Lepping, Reske: "Synthesis and biologic study of IV-14, a new ribonucleoside radiotracer for tumor visualization." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Vol. 50, Issue 11, pp. 1895-903, (2009) (PubMed).

Target Details for UCK

Target: UCK (Uridine-Cytidine Kinase (UCK))

Alternative Name: UCK (UCK Products)

Background: UCK1 (Uridine-cytidine kinase 1) phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. This enzyme does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Of note, UCK1 is able to use either ATP or GTP as a phosphate donor. UCK1 also possesses the ability to phosphorylate a number of cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.

Molecular Weight: 22222

Gene ID: 51727

NCBI Accession: NP_001129612, NP_057392

UniProt: P30085

Pathways: Nucleotide Phosphorylation