TLK2 antibody (AA 141-171)

Catalog No. ABIN392686

Product Details anti-TLK2 Antibody

Target: TLK2 (Tousled-Like Kinase 2 (TLK2))

Binding Specificity: AA 141-171

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLK2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This TLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-171 amino acids from the Central region of human TLK2.

Clone: RB3046

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for TLK2

Target: TLK2 (Tousled-Like Kinase 2 (TLK2))

Alternative Name: TLK2 (TLK2 Products)

Synonyms: tlk2 antibody, MGC149057 antibody, HsHPK antibody, PKU-ALPHA antibody, wu:fi16h09 antibody, wu:fi30g12 antibody, zgc:136697 antibody, 4933403M19Rik antibody, PKUalpha antibody, Tlk antibody, tousled like kinase 2 antibody, tousled-like kinase 2 antibody, tousled-like kinase 2 (Arabidopsis) antibody, tlk2 antibody, TLK2 antibody, Tlk2 antibody

Background: TLK2, a member of the Ser/Thr protein kinase family, is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.

Molecular Weight: 87661

Gene ID: 11011

NCBI Accession: NP_001106178, NP_006843

UniProt: Q86UE8