MAP3K10 antibody (C-Term)

Catalog No. ABIN392424

Product Details anti-MAP3K10 Antibody

Target: MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10 (MAP3K10))

Binding Specificity: AA 628-659, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 628-659 amino acids from the C-terminal region of human MLK2.

Clone: RB0986

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-MAP3K10 antibody (ABIN392424)

Humphrey, Newcomb, Yu, Hao, Yu, Krajewski, Du, Jhala: "Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22426-36, (2010) (PubMed).

Nagao, Hayashi: "Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease." in: Journal of the neurological sciences, Vol. 281, Issue 1-2, pp. 51-4, (2009) (PubMed).

Target Details for MAP3K10

Target: MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10 (MAP3K10))

Alternative Name: MLK2 (MAP3K10 Products)

Synonyms: MEKK10 antibody, MLK2 antibody, MST antibody, BC028668 antibody, BC046514 antibody, Mlk2 antibody, mlk2 antibody, xmlk2 antibody, mitogen-activated protein kinase kinase kinase 10 antibody, mitogen activated protein kinase kinase kinase 10 antibody, mitogen-activated protein kinase kinase kinase 10 L homeolog antibody, MAP3K10 antibody, Map3k10 antibody, map3k10.L antibody

Background: MLK2 is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.

Molecular Weight: 103694

Gene ID: 4294

NCBI Accession: NP_002437

UniProt: Q02779