MAP3K9 antibody (C-Term)

Catalog No. ABIN392422

Product Details anti-MAP3K9 Antibody

Target: MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9 (MAP3K9))

Binding Specificity: AA 1070-1104, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K9 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MLK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1070-1104 amino acids from the C-terminal region of human MLK1.

Clone: RB0983

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-MAP3K9 antibody (ABIN392422)

Polesskaya, Cunningham, Francis, Luebke, Zhu, Collins, Vasilyeva, Sahler, Desmet, Gelbard, Maggirwar, Walton, Frisina, Dewhurst: "Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure." in: Hearing research, Vol. 270, Issue 1-2, pp. 21-7, (2011) (PubMed).

Humphrey, Newcomb, Yu, Hao, Yu, Krajewski, Du, Jhala: "Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22426-36, (2010) (PubMed).

Strath, Georgopoulos, Kellam, Blair: "Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation." in: BMC genomics, Vol. 10, pp. 67, (2009) (PubMed).

Target Details for MAP3K9

Target: MAP3K9 (Mitogen-Activated Protein Kinase Kinase Kinase 9 (MAP3K9))

Alternative Name: MLK1 (MAP3K9 Products)

Synonyms: MEKK9 antibody, MLK1 antibody, PRKE1 antibody, E130314H24Rik antibody, Mlk1 antibody, Prke1 antibody, RGD1562149 antibody, mitogen-activated protein kinase kinase kinase 9 antibody, MAP3K9 antibody, Map3k9 antibody

Background: MLK1 is a MLK(MAP3K) type protein kinase. The catalytic domain of mixed-lineage kinases (MLKs) kinases have amino acid sequence similarity to both the tyr-specific and the ser/thr-specific kinase classes. In addition to thee unusual nature of the kinase catalytic domains, MLK1 and MLK2 contain 2 leu/ile-zipper motifs and a basic sequence near their C-termini. MLK1 is a member of the neuronal apoptotic JNK/c-Jun pathway acting between Rac1/Cdc42 and MKK4 and -7 in death signaling. MLK1 expression has been documented in human epithelial tumor cell lines of colonic, breast and esophageal origin.

Molecular Weight: 121895

Gene ID: 4293

NCBI Accession: NP_149132

UniProt: P80192