IRAK3 antibody (N-Term)

Catalog No. ABIN392236

Product Details anti-IRAK3 Antibody

Target: IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))

Binding Specificity: AA 45-77, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRAK3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This IRAK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-77 amino acids from the N-terminal region of human IRAK3.

Clone: RB2344

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:500. IHC-P: 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for IRAK3

Target: IRAK3 (Interleukin-1 Receptor-Associated Kinase 3 (IRAK3))

Alternative Name: IRAK3 (IRAK3 Products)

Synonyms: IRAK3 antibody, si:dkey-150i15.2 antibody, ASRT5 antibody, IRAKM antibody, IrakM antibody, 4833428C18Rik antibody, AI563835 antibody, IRAK-M antibody, interleukin 1 receptor associated kinase 3 antibody, interleukin-1 receptor-associated kinase 3 antibody, IRAK3 antibody, irak3 antibody, Irak3 antibody

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine-like kinase (TLK) group consists of 40 tyrosine and serine-threonine kinases such as MLK (mixed-lineage kinase), LISK (LIMK/TESK), IRAK (interleukin-1 receptor-associated kinase), Raf, RIPK (receptor-interacting protein kinase), and STRK (activin and TGF-beta receptors) families.

Molecular Weight: 67767

Gene ID: 11213

NCBI Accession: NP_001135995, NP_009130

UniProt: Q9Y616

Pathways: TLR Signaling, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades