LTK antibody (N-Term)

Catalog No. ABIN392012

Product Details anti-LTK Antibody

Target: LTK (Leukocyte Receptor tyrosine Kinase (LTK))

Binding Specificity: AA 42-72, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LTK antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This LTK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-72 amino acids from the N-terminal region of human LTK.

Clone: RB1528

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for LTK

Target: LTK (Leukocyte Receptor tyrosine Kinase (LTK))

Alternative Name: LTK (LTK Products)

Synonyms: LTK antibody, ALK antibody, TYK1 antibody, si:dz107o16.1 antibody, leukocyte receptor tyrosine kinase antibody, leukocyte tyrosine kinase antibody, Ltk antibody, LTK antibody, ltk antibody

Background: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Molecular Weight: 91681

Gene ID: 4058

NCBI Accession: NP_001129157, NP_002335, NP_996844

UniProt: P29376

Pathways: RTK Signaling